autoimmune disorders — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T12311	Tirabrutinib hydrochloride	ONO-4059 (hydrochloride),GS-4059 (hydrochloride)	BTK
	Tirabrutinib hydrochloride (GS-4059 (hydrochloride)) is a selective and novelBTK with IC50 2.2 nm inhibitor.		BTK
T10009	JAK3-IN-7		JAK
	JAK3-IN-7 is a potent and selective JAK3 inhibitor (IC50<0.01 μM) for the treatment of rejection in organ transplantation, graft-versus-host reaction after organ transplantation, autoimmune disorders, allergic diseases, ...		JAK
T21694	(R)-Lisofylline	(R)-Lisophylline	STAT
	(R)-Lisofylline ((R)-Lisophylline) is an inhibitor of lysophosphatidic acid acyltransferase (IC50 = 0.6 µM). (R)-Lisofylline interrupts IL-12 signaling-mediated STAT4 activation and can be used in studies about the treat...		STAT
TQ0295	Coumestrol		Estrogen Receptor/ERR
	Coumestrol that existed in soybean products suppresses the proliferation of ES2 cells (IC50: 50 μM). It exhibits activities against neurological disorders, cancers and autoimmune diseases.		Estrogen Receptor/ERR
T38723	β-Aminoarteether	β-Aminoarteether,SM934 free base	Others
	β-Aminoarteether (SM934 free base), an orally active derivative of Artemisinin, serves a pivotal role in the research of inflammation and autoimmune disorders, including those related to lupus diseases.		Others
T7503	Upadacitinib	ABT-494	JAK
	Upadacitinib (ABT-494) (ABT-494) is a selective Janus kinase (JAK) 1 inhibitor, which is being studied for the treatment of several autoimmune disorders in the IC50 of 43 nM.		JAK
T77727	Feeblin	IRF5-IN-1	Others
	Feeblin（IRF5-IN-1） is a protein degradation inducer that specifically blocks pro-inflammatory signaling pathways associated with autoimmune diseases and can be used to study immune system disorders in the class of system...		Others
T60060	ACSS2-IN-2	MTB-9655	Fatty Acid Synthase
	ACSS2-IN-2 (MTB-9655) is an inhibitor of acyl-CoA synthetase short-chain family member 2 (ACSS2). ACSS2-IN-2 can inhibit ACSS2 activity with an IC50 value of 3.8 nM. ACSS2-IN-2 can be used for the research of several dis...		Fatty Acid Synthase
T35569	CTA 056		Apoptosis
	CTA 056 is an interleukin-2 induced T cell kinase (ITK) inhibitor, inhibits the growth of MOLT-4 xenograft tumors in mice, induces apoptosis in Jurkat cells, and can be used in the study of autoimmune disorders and T cel...		Apoptosis
T13388	Zaurategrast ethyl ester sulfate	UCB1184197 sulfate,CDP323 sulfate	Others
	Zaurategrast ethyl ester sulfate is a α4β1/α4β7 integrin antagonist, and used for the treatment of inflammatory and autoimmune disorders.		Others
T28143	ND-2110	ND2110
	ND-2110, a selective interleukin-1 receptor-associated kinase 4 inhibitors, is used for the treatment of autoimmune disorders and lymphoid malignancy.
T39097	Zectivimod
	Zectivimod, a sphingosine-1-phosphate receptor agonist, holds the potential for studying autoimmune diseases, chronic inflammatory diseases, and immunoregulation disorders.
T13388L	Zaurategrast ethyl ester	UCB1184197,CDP323	Others
	Zaurategrast ethyl ester is the ethyl ester prodrug of CT7758 and is an α4β1/α4β7 integrin antagonist. It is used for the treatment of inflammatory and autoimmune disorders.		Others
T40354	IL-17A modulator-1
	IL-17A modulator-1 is an effective inhibitor of IL-17A activity, exhibiting a pIC 50 value of 8.2. This compound holds great promise for studying diseases and disorders that involve the modulation of IL-17A, such as immu...
T81107	SR-29065
	SR-29065 is a selective agonist of REV-ERBα, utilized in the research of autoimmune disorders [1].
T61332	MRGPRX4 modulator-1
	MRGPRX4 modulator-1 (compound 31-2) is a potent antagonist of the mas-related g-protein receptor X4 (MRGPR X4) with an IC50 < 100 nM against MRGPR4. It is utilized for the investigation of MRGPR X4 dependent diseases inc...
T78205	ROCK2-IN-6 hydrochloride		ROCK
	ROCK2-IN-6 hydrochloride (Comp A) serves as a selective inhibitor of ROCK2, applicable for research into ROCK-mediated diseases, autoimmune disorders, and inflammation [1].		ROCK
T78744	IRAK4-IN-24		IRAK
	IRAK4-IN-24 (compound 16), a potent IRAK4 inhibitor, exhibits high clearance (Cl) and low oral bioavailability. It is utilized in research pertaining to inflammatory and autoimmune disorders.		IRAK
T80645	4-Methylhistamine		Histamine Receptor
	4-Methylhistamine serves as a potent agonist for the histamine 4 receptor (H4R), holding promise for research into immune-related diseases, including cancer and autoimmune disorders [1] [2].		Histamine Receptor
T72596	RORγt modulator 5
	RORγt modulator 5, a potent RORγt modulator, exhibits a dissociation constant (K_i) of <100 nM. This compound holds promise for the treatment of diseases mediated by RORγ, including inflammatory, metabolic, and autoimmun...